Common Genetic Variants of MGP Are Associated With Calcification on the Arterial Wall but Not With Calcification Present in the Atherosclerotic Plaques | Zendy

Yibo Wang | Zendy; Jinxing Chen | Zendy; Yu Zhang | Zendy; Weifeng Yu | Zendy; Channa Zhang | Zendy; Ling Gong | Zendy; Liying Shao | Zendy; Jin-guo Lu | Zendy; Yang Gao | Zendy; Xuannan Chen | Zendy; Xi Chen | Zendy; Rutai Hui | Zendy

Open Access

Common Genetic Variants of MGP Are Associated With Calcification on the Arterial Wall but Not With Calcification Present in the Atherosclerotic Plaques

Author(s) -

Yibo Wang,

Jinxing Chen,

Yu Zhang,

Weifeng Yu,

Channa Zhang,

Ling Gong,

Liying Shao,

Jin-guo Lu,

Yang Gao,

Xuannan Chen,

Xi Chen,

Rutai Hui

Publication year - 2013

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.113.000003

Subject(s) - calcification , matrix gla protein , medicine , cardiology , calcinosis , confidence interval , aorta , coronary arteries , artery , odds ratio , ectopic calcification

Two endophenotypes of arterial calcification, calcification on arterial wall and calcification in atherosclerotic plaques, are associated with different types of cardiovascular events. Mgp-deficient mice showed matrix Gla protein (MGP) is strongly associated with calcification on arterial wall without atherosclerotic plaques, and MGP variants were not significantly associated with myocardial infarction. MGP may play different roles in the 2 endophenotypes.

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