Open AccessProteomic Identification of Matrix Metalloproteinase Substrates in the Human Vasculature
Author(s) -
Christin Stegemann,
Athanasios Didangelos,
Javier BarallobreBarreiro,
Sarah R. Langley,
Kaushik Mandal,
Marjan Jahangiri,
Manuel Mayr
Publication year - 2012
Publication title -
circulation cardiovascular genetics
Language(s) - English
Resource type - Journals
eISSN - 1942-325X
pISSN - 1942-3268
DOI - 10.1161/circgenetics.112.964452
Subject(s) - matrix metalloproteinase , periostin , extracellular matrix , proteomics , collagenase , chemistry , microbiology and biotechnology , basement membrane , quantitative proteomics , biology , biochemistry , enzyme , gene
Matrix metalloproteinases (MMPs) play a key role in cardiovascular disease, in particular aneurysm formation and plaque rupture. Surprisingly, little is known about MMP substrates in the vasculature.
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