Pooled DNA Resequencing of 68 Myocardial Infarction Candidate Genes in French Canadians | Zendy

Mélissa Beaudoin | Zendy; Ken Sin Lo | Zendy; Amidou N’Diaye | Zendy; Manuel A. Rivas | Zendy; MariePierre Dubé | Zendy; Nathalie Laplante | Zendy; Michael Phillips | Zendy; John D. Rioux | Zendy; JeanClaude Tardif | Zendy; Guillaume Lettre | Zendy

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Pooled DNA Resequencing of 68 Myocardial Infarction Candidate Genes in French Canadians

Author(s) -

Mélissa Beaudoin,

Ken Sin Lo,

Amidou N’Diaye,

Manuel A. Rivas,

MariePierre Dubé,

Nathalie Laplante,

Michael Phillips,

John D. Rioux,

JeanClaude Tardif,

Guillaume Lettre

Publication year - 2012

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.112.963165

Subject(s) - myocardial infarction , gene , candidate gene , genetics , medicine , biology

Familial history is a strong risk factor for coronary artery disease (CAD), especially for early-onset myocardial infarction (MI). Several genes and chromosomal regions have been implicated in the genetic cause of coronary artery disease/MI, mostly through the discovery of familial mutations implicated in hyper-/hypocholesterolemia by linkage studies and single nucleotide polymorphisms by genome-wide association studies. Except for a few examples (eg, PCSK9), the role of low-frequency genetic variation (minor allele frequency [MAF]) ≈0.1%-5% on MI/coronary artery disease predisposition has not been extensively investigated.

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