Causal Relevance of Blood Lipid Fractions in the Development of Carotid Atherosclerosis | Zendy

Sonia Shah | Zendy; JuanPablo Casas | Zendy; Fotios Drenos | Zendy; John C. Whittaker | Zendy; John Deanfield | Zendy; Daniel I. Swerdlow | Zendy; Michael V. Holmes | Zendy; Mika Kivimäki | Zendy; Claudia Langenberg | Zendy; Nicholas J. Wareham | Zendy; Karl Gertow | Zendy; Bengt Sennblad | Zendy; Rona J. Strawbridge | Zendy; Damiano Baldassarre | Zendy; Fabrizio Veglia | Zendy; Elena Tremoli | Zendy; Bruna Gigante | Zendy; Ulf dé Fairé | Zendy; Meena Kumari | Zendy; Philippa J. Talmud | Zendy; Anders Hamsten | Zendy; Steve E. Humphries | Zendy; Aroon D. Hingorani | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Causal Relevance of Blood Lipid Fractions in the Development of Carotid Atherosclerosis

Author(s) -

Sonia Shah,

JuanPablo Casas,

Fotios Drenos,

John C. Whittaker,

John Deanfield,

Daniel I. Swerdlow,

Michael V. Holmes,

Mika Kivimäki,

Claudia Langenberg,

Nicholas J. Wareham,

Karl Gertow,

Bengt Sennblad,

Rona J. Strawbridge,

Damiano Baldassarre,

Fabrizio Veglia,

Elena Tremoli,

Bruna Gigante,

Ulf dé Fairé,

Meena Kumari,

Philippa J. Talmud,

Anders Hamsten,

Steve E. Humphries,

Aroon D. Hingorani

Publication year - 2012

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.112.963140

Subject(s) - mendelian randomization , medicine , cholesterol , cardiology , confidence interval , lipoprotein , intima media thickness , high density lipoprotein , genome wide association study , single nucleotide polymorphism , endocrinology , genetics , biology , genotype , carotid arteries , gene , genetic variants

Carotid intima-media thickness (CIMT), a subclinical measure of atherosclerosis, is associated with risk of coronary heart disease events. Statins reduce progression of CIMT and coronary heart disease risk in proportion to the reduction in low-density lipoprotein cholesterol. However, interventions targeting triglycerides (TGs) or high-density lipoprotein cholesterol (HDL-C) have produced inconsistent effects on CIMT and coronary heart disease risk, making it uncertain whether such agents are ineffective for coronary heart disease prevention or whether CIMT is an inadequate marker of HDL-C or TG-mediated effects. We aimed to determine the causal association among the 3 major blood lipid fractions and common CIMT using mendelian randomization analysis.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research