Impact of Ancestry and Common Genetic Variants on QT Interval in African Americans | Zendy

J. Gustav Smith | Zendy; Christy L. Avery | Zendy; Daniel S. Evans | Zendy; Michael A. Nalls | Zendy; Yan Meng | Zendy; Erin N. Smith | Zendy; Nicholette D. Palmer | Zendy; Toshiko Tanaka | Zendy; Reena Mehra | Zendy; Anne M. Butler | Zendy; Taylor R. Young | Zendy; Sarah G. Buxbaum | Zendy; Kathleen F. Kerr | Zendy; Gerald S. Berenson | Zendy; Renate B. Schnabel | Zendy; Guo Li | Zendy; Patrick T. Ellinor | Zendy; Jared W. Magnani | Zendy; Wei Chen | Zendy; Joshua C. Bis | Zendy; J. David Curb | Zendy; Wen-Chi Hsueh | Zendy; Jerome I Rotter | Zendy; Yongmei Liu | Zendy; Anne B. Newman | Zendy; Marian C. Limacher | Zendy; Kari E. North | Zendy; Alexander P. Reiner | Zendy; P. Miguel Quibrera | Zendy; Nicholas J. Schork | Zendy; Andrew B. Singleton | Zendy; Bruce M. Psaty | Zendy; Elsayed Z. Soliman | Zendy; Allen J. Solomon | Zendy; Sathanur R. Srinivasan | Zendy; Álvaro Alonso | Zendy; Robert B. Wallace | Zendy; Susan Redline | Zendy; Zhu-Ming Zhang | Zendy; Wendy S. Post | Zendy; Alan B. Zonderman | Zendy; Herman A. Taylor | Zendy; Sarah S. Murray | Zendy; Luigi Ferrucci | Zendy; Dan E. Arking | Zendy; Michele K. Evans | Zendy; Ervin R. Fox | Zendy; a Sotoodehnia | Zendy; Susan R. Heckbert | Zendy; Eric A. Whitsel | Zendy; Christopher NewtonCheh | Zendy

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Impact of Ancestry and Common Genetic Variants on QT Interval in African Americans

Author(s) -

J. Gustav Smith,

Christy L. Avery,

Daniel S. Evans,

Michael A. Nalls,

Yan Meng,

Erin N. Smith,

Nicholette D. Palmer,

Toshiko Tanaka,

Reena Mehra,

Anne M. Butler,

Taylor R. Young,

Sarah G. Buxbaum,

Kathleen F. Kerr,

Gerald S. Berenson,

Renate B. Schnabel,

Guo Li,

Patrick T. Ellinor,

Jared W. Magnani,

Wei Chen,

Joshua C. Bis,

J. David Curb,

Wen-Chi Hsueh,

Jerome I Rotter,

Yongmei Liu,

Anne B. Newman,

Marian C. Limacher,

Kari E. North,

Alexander P. Reiner,

P. Miguel Quibrera,

Nicholas J. Schork,

Andrew B. Singleton,

Bruce M. Psaty,

Elsayed Z. Soliman,

Allen J. Solomon,

Sathanur R. Srinivasan,

Álvaro Alonso,

Robert B. Wallace,

Susan Redline,

Zhu-Ming Zhang,

Wendy S. Post,

Alan B. Zonderman,

Herman A. Taylor,

Sarah S. Murray,

Luigi Ferrucci,

Dan E. Arking,

Michele K. Evans,

Ervin R. Fox,

a Sotoodehnia,

Susan R. Heckbert,

Eric A. Whitsel,

Christopher NewtonCheh

Publication year - 2012

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.112.962787

Subject(s) - qt interval , single nucleotide polymorphism , genome wide association study , genetic genealogy , genetic association , imputation (statistics) , snp , genetics , sudden cardiac death , biology , population , long qt syndrome , minor allele frequency , ancestry informative marker , medicine , genotype , gene , environmental health , machine learning , missing data , computer science

Ethnic differences in cardiac arrhythmia incidence have been reported, with a particularly high incidence of sudden cardiac death and low incidence of atrial fibrillation in individuals of African ancestry. We tested the hypotheses that African ancestry and common genetic variants are associated with prolonged duration of cardiac repolarization, a central pathophysiological determinant of arrhythmia, as measured by the electrocardiographic QT interval.

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