High Prevalence of Long QT Syndrome–Associated SCN5A Variants in Patients With Early-Onset Lone Atrial Fibrillation | Zendy

Morten S. Olesen | Zendy; Lei Yuan | Zendy; Bo Liang | Zendy; Anders G. Holst | Zendy; Nikolaj Nielsen | Zendy; Jonas B. Nielsen | Zendy; Paula L. Hedley | Zendy; Michael Christiansen | Zendy; SørenPeter Olesen | Zendy; Stig Haunsø | Zendy; Nicole Schmitt | Zendy; Thomas Jespersen | Zendy; Jesper Hastrup Svendsen | Zendy

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High Prevalence of Long QT Syndrome–Associated SCN5A Variants in Patients With Early-Onset Lone Atrial Fibrillation

Author(s) -

Morten S. Olesen,

Lei Yuan,

Bo Liang,

Anders G. Holst,

Nikolaj Nielsen,

Jonas B. Nielsen,

Paula L. Hedley,

Michael Christiansen,

SørenPeter Olesen,

Stig Haunsø,

Nicole Schmitt,

Thomas Jespersen,

Jesper Hastrup Svendsen

Publication year - 2012

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.111.962597

Subject(s) - proband , nonsynonymous substitution , atrial fibrillation , medicine , long qt syndrome , population , sodium channel , genetics , minor allele frequency , missense mutation , cardiology , allele frequency , mutation , biology , allele , qt interval , gene , chemistry , environmental health , organic chemistry , genome , sodium

Atrial fibrillation (AF) is the most common cardiac arrhythmia. The cardiac sodium channel, Na(V)1.5, plays a pivotal role in setting the conduction velocity and the initial depolarization of the cardiac myocytes. We hypothesized that early-onset lone AF was associated with genetic variation in SCN5A.

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