Fine Mapping Study Reveals Novel Candidate Genes for Carotid Intima-Media Thickness in Dominican Republican Families | Zendy

Liyong Wang | Zendy; Ashley Beecham | Zendy; Degen Zhuo | Zendy; Chuanhui Dong | Zendy; Susan H. Blanton | Zendy; Tatjana Rundek | Zendy; Ralph L. Sacco | Zendy

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Fine Mapping Study Reveals Novel Candidate Genes for Carotid Intima-Media Thickness in Dominican Republican Families

Author(s) -

Liyong Wang,

Ashley Beecham,

Degen Zhuo,

Chuanhui Dong,

Susan H. Blanton,

Tatjana Rundek,

Ralph L. Sacco

Publication year - 2012

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.111.961763

Subject(s) - single nucleotide polymorphism , genetics , candidate gene , population , biology , quantitative trait locus , haplotype , genetic linkage , snp , genetic association , linkage disequilibrium , odds ratio , linkage (software) , gene , genotype , medicine , environmental health

Carotid intima-media thickness (CIMT) is a subclinical measure for atherosclerosis. Previously, we have mapped quantitative trait loci (QTLs) for CIMT to chromosomes 7p (maximum logarithm of odds=3.1) and to 14q (maximum logarithm of odds=2.3). We sought to identify the underlying genetic variants within those QTLs.

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