A Large Candidate Gene Survey Identifies the KCNE1 D85N Polymorphism as a Possible Modulator of Drug-Induced Torsades de Pointes | Zendy

Stefan Kääb | Zendy; Dana C. Crawford | Zendy; Moritz F. Sinner | Zendy; Elijah R. Behr | Zendy; Prince J. Kannankeril | Zendy; Arthur A.M. Wilde | Zendy; Connie R. Bezzina | Zendy; Eric SchulzeBahr | Zendy; Pascale Guicheney | Zendy; Nanette H. Bishopric | Zendy; Robert J. Myerburg | Zendy; JeanJacques Schott | Zendy; Arne Pfeufer | Zendy; Britt Maria Beckmann | Zendy; Eimo Martens | Zendy; Taifang Zhang | Zendy; Birgit Stallmeyer | Zendy; Sven Zumhagen | Zendy; Isabelle Denjoy | Zendy; Abdennasser Bardai | Zendy; Isabelle C. Van Gelder | Zendy; Yalda Jamshidi | Zendy; Chrysoula Dalageorgou | Zendy; Vanessa Marshall | Zendy; Steve Jeffery | Zendy; Saad Shakir | Zendy; A. John Camm | Zendy; Gerhard Steinbeck | Zendy; Siegfried Perz | Zendy; Peter Lichtner | Zendy; Thomas Meitinger | Zendy; Annette Peters | Zendy; H-Erich Wichmann | Zendy; Christiana D. Ingram | Zendy; Yuki Bradford | Zendy; Shan Carter | Zendy; Kris Norris | Zendy; Marylyn D. Ritchie | Zendy; Alfred L. George | Zendy; Dan M. Roden | Zendy

Open Access

A Large Candidate Gene Survey Identifies the KCNE1 D85N Polymorphism as a Possible Modulator of Drug-Induced Torsades de Pointes

Author(s) -

Stefan Kääb,

Dana C. Crawford,

Moritz F. Sinner,

Elijah R. Behr,

Prince J. Kannankeril,

Arthur A.M. Wilde,

Connie R. Bezzina,

Eric SchulzeBahr,

Pascale Guicheney,

Nanette H. Bishopric,

Robert J. Myerburg,

JeanJacques Schott,

Arne Pfeufer,

Britt Maria Beckmann,

Eimo Martens,

Taifang Zhang,

Birgit Stallmeyer,

Sven Zumhagen,

Isabelle Denjoy,

Abdennasser Bardai,

Isabelle C. Van Gelder,

Yalda Jamshidi,

Chrysoula Dalageorgou,

Vanessa Marshall,

Steve Jeffery,

Saad Shakir,

A. John Camm,

Gerhard Steinbeck,

Siegfried Perz,

Peter Lichtner,

Thomas Meitinger,

Annette Peters,

H-Erich Wichmann,

Christiana D. Ingram,

Yuki Bradford,

Shan Carter,

Kris Norris,

Marylyn D. Ritchie,

Alfred L. George,

Dan M. Roden

Publication year - 2011

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.111.960930

Subject(s) - torsades de pointes , single nucleotide polymorphism , qt interval , long qt syndrome , odds ratio , population , candidate gene , allele frequency , snp , genetics , pharmacogenomics , nonsynonymous substitution , haplotype , pharmacogenetics , population stratification , medicine , allele , biology , genotype , gene , environmental health , genome

Drug-induced long-QT syndrome (diLQTS) is an adverse drug effect that has an important impact on drug use, development, and regulation. We tested the hypothesis that common variants in key genes controlling cardiac electric properties modify the risk of diLQTS.

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