Literature-Based Genetic Risk Scores for Coronary Heart Disease | Zendy

Anika A. M. Vaarhorst | Zendy; Yingchang Lu | Zendy; Bastiaan T. Heijmans | Zendy; Martijn E.T. Dollé | Zendy; Stefan Böhringer | Zendy; Hein Putter | Zendy; Sandra Imholz | Zendy; Audrey H. H. Merry | Zendy; Marleen M. J. van Greevenbroek | Zendy; J. Wouter Jukema | Zendy; Anton P.M. Gorgels | Zendy; Piet A. van den Brandt | Zendy; Michael Müller | Zendy; Leo J. Schouten | Zendy; Edith J. M. Feskens | Zendy; Jolanda M.A. Boer | Zendy; P. Eline Slagboom | Zendy

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Literature-Based Genetic Risk Scores for Coronary Heart Disease

Author(s) -

Anika A. M. Vaarhorst,

Yingchang Lu,

Bastiaan T. Heijmans,

Martijn E.T. Dollé,

Stefan Böhringer,

Hein Putter,

Sandra Imholz,

Audrey H. H. Merry,

Marleen M. J. van Greevenbroek,

J. Wouter Jukema,

Anton P.M. Gorgels,

Piet A. van den Brandt,

Michael Müller,

Leo J. Schouten,

Edith J. M. Feskens,

Jolanda M.A. Boer,

P. Eline Slagboom

Publication year - 2012

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.111.960708

Subject(s) - single nucleotide polymorphism , genome wide association study , medicine , hazard ratio , snp , confidence interval , cohort , lasso (programming language) , minor allele frequency , proportional hazards model , oncology , genetics , genotype , biology , world wide web , gene , computer science

Genome-wide association studies (GWAS) have identified many single-nucleotide polymorphisms (SNPs) associated with coronary heart disease (CHD) or CHD risk factors (RF). Using a case-cohort study within the prospective Cardiovascular Registry Maastricht (CAREMA) cohort, we tested if genetic risk scores (GRS) based on GWAS-identified SNPs are associated with and predictive for future CHD.

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