Protein Interaction-Based Genome-Wide Analysis of Incident Coronary Heart Disease | Zendy

Majken K. Jensen | Zendy; Tune H. Pers | Zendy; Piotr Dworzyński | Zendy; Cynthia J. Girman | Zendy; Søren Brunak | Zendy; Eric B. Rimm | Zendy

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Protein Interaction-Based Genome-Wide Analysis of Incident Coronary Heart Disease

Author(s) -

Majken K. Jensen,

Tune H. Pers,

Piotr Dworzyński,

Cynthia J. Girman,

Søren Brunak,

Eric B. Rimm

Publication year - 2011

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.111.960393

Subject(s) - gene , single nucleotide polymorphism , genome wide association study , genetics , candidate gene , genome , biology , computational biology , disease , genetic association , bioinformatics , medicine , genotype

Network-based approaches may leverage genome-wide association (GWA) analysis by testing for the aggregate association across several pathway members. We aimed to examine if networks of genes that represent experimentally determined protein-protein interactions (PPIs) are enriched in genes associated with risk of coronary heart disease (CHD).

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