Association of Known Loci With Lipid Levels Among Children and Prediction of Dyslipidemia in Adults | Zendy

Emmi Tikkanen | Zendy; Tarja Tuovinen | Zendy; Elisabeth Widén | Zendy; Terho Lehtimäki | Zendy; Jorma Viikari | Zendy; Mika Kähönen | Zendy; Leena Peltonen | Zendy; Olli T. Raitakari | Zendy; Samuli Ripatti | Zendy

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Association of Known Loci With Lipid Levels Among Children and Prediction of Dyslipidemia in Adults

Author(s) -

Emmi Tikkanen,

Tarja Tuovinen,

Elisabeth Widén,

Terho Lehtimäki,

Jorma Viikari,

Mika Kähönen,

Leena Peltonen,

Olli T. Raitakari,

Samuli Ripatti

Publication year - 2011

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.111.960369

Subject(s) - dyslipidemia , association (psychology) , genetics , genetic association , biology , medicine , psychology , single nucleotide polymorphism , genotype , gene , obesity , psychotherapist

Recent genome-wide association studies have found 95 distinct genetic loci associated with high-density (HDL-C) and low-density (LDL-C) lipoprotein cholesterol, total cholesterol (TC), and triglycerides (TG), using adult samples. It is not known if these variants are associated with lipid levels in children and adolescents and if the genetic risk score (GRS), based on these variants, could improve adulthood dyslipidemia prediction over the childhood lipid measurements.

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