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Common Genetic Variation in the 3′- BCL11B Gene Desert Is Associated With Carotid-Femoral Pulse Wave Velocity and Excess Cardiovascular Disease Risk
Author(s) -
Gary F. Mitchell,
Germaine C. Verwoert,
Kirill V. Tarasov,
Aaron Isaacs,
Albert V. Smith,
Yasmin Yasmin,
Ernst Rietzschel,
Toshiko Tanaka,
ChingTi Liu,
Afshin Parsa,
Samer S. Najjar,
Kevin M. O’Shaughnessy,
Sigurður Sigurdsson,
Marc De Buyzere,
Martin G. Larson,
Mark P.S. Sie,
Jeanette S. Andrews,
Wendy S. Post,
Francesco MattaceRaso,
Carmel M. McEniery,
Guðný Eiríksdóttir,
Patrick Segers,
Ramachandran S. Vasan,
Marie Josee E. van Rijn,
Timothy D. Howard,
Patrick F. McArdle,
Abbas Dehghan,
Elizabeth S. Jewell,
Stephen Newhouse,
Sofie Bekaert,
Naomi M. Hamburg,
Anne B. Newman,
Albert Hofman,
Angelo Scuteri,
Dirk De Bacquer,
M. Arfan Ikram,
Bruce M. Psaty,
Christian Fuchsberger,
Matthias Olden,
Louise V. Wain,
Paul Elliott,
Nicholas L. Smith,
Janine F. Felix,
Jeanette Erdmann,
Joseph A. Vita,
Kim SuttonTyrrell,
Eric J.G. Sijbrands,
Serena Sanna,
Lenore J. Launer,
Tim De Meyer,
Andrew D. Johnson,
Anna FC Schut,
David M. Herrington,
Fernando Rivadeneira,
Manuela Uda,
Ian B. Wilkinson,
Thor Aspelund,
Thierry Gillebert,
Luc Van Bortel,
Emelia J. Benjamin,
Ben A. Oostra,
Jingzhong Ding,
Quince Gibson,
André G. Uitterlinden,
Gonçalo R. Abecasis,
John R. Cockcroft,
Vilmundur Guðnason,
Guy De Backer,
Luigi Ferrucci,
Tamara B. Harris,
Alan R. Shuldiner,
Cornelia M. van Duijn,
Daniel Levy,
Edward G. Lakatta,
Jacqueline C.M. Witteman
Publication year - 2011
Publication title -
circulation cardiovascular genetics
Language(s) - English
Resource type - Journals
eISSN - 1942-3268
pISSN - 1942-325X
DOI - 10.1161/circgenetics.111.959817
Subject(s) - pulse wave velocity , hazard ratio , allele , medicine , locus (genetics) , arterial stiffness , minor allele frequency , pulse pressure , confidence interval , cardiology , coronary artery disease , allele frequency , genetics , blood pressure , biology , gene
Carotid-femoral pulse wave velocity (CFPWV) is a heritable measure of aortic stiffness that is strongly associated with increased risk for major cardiovascular disease events.

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