Open AccessMOG1
Author(s) -
Darouna Kattygnarath,
Svetlana Maugenre,
Nathalie Neyroud,
Elise Balse,
Carole Ichaï,
Isabelle Denjoy,
Gilles Dilanian,
Raphaël P. Martins,
Véronique Fressart,
Myriam Berthet,
JeanJacques Schott,
Antoine Leenhardt,
Vincent Probst,
Hervé Le Marec,
Bernard Hainque,
Alain Coulombe,
Stéphane N. Hatem,
Pascale Guicheney
Publication year - 2011
Publication title -
circulation cardiovascular genetics
Language(s) - English
Resource type - Journals
eISSN - 1942-325X
pISSN - 1942-3268
DOI - 10.1161/circgenetics.110.959130
Subject(s) - medicine , computational biology , biology
Brugada syndrome (BrS) is caused mainly by mutations in the SCN5A gene, which encodes the α-subunit of the cardiac sodium channel Na(v)1.5. However, ≈ 20% of probands have SCN5A mutations, suggesting the implication of other genes. MOG1 recently was described as a new partner of Na(v)1.5, playing a potential role in the regulation of its expression and trafficking. We investigated whether mutations in MOG1 could cause BrS.
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