PITX2c Is Expressed in the Adult Left Atrium, and Reducing Pitx2c Expression Promotes Atrial Fibrillation Inducibility and Complex Changes in Gene Expression | Zendy

Paulus Kirchhof | Zendy; Peter C. Kahr | Zendy; Sven Kaese | Zendy; Ilaria Piccini | Zendy; Ismail Vokshi | Zendy; H. H. Scheld | Zendy; Heinrich Rotering | Zendy; Lisa Fortmueller | Zendy; Sandra Laakmann | Zendy; Sander Verheule | Zendy; Ulrich Schotten | Zendy; Larissa Fabritz | Zendy; Nigel A. Brown | Zendy

Open Access

PITX2c Is Expressed in the Adult Left Atrium, and Reducing Pitx2c Expression Promotes Atrial Fibrillation Inducibility and Complex Changes in Gene Expression

Author(s) -

Paulus Kirchhof,

Peter C. Kahr,

Sven Kaese,

Ilaria Piccini,

Ismail Vokshi,

H. H. Scheld,

Heinrich Rotering,

Lisa Fortmueller,

Sandra Laakmann,

Sander Verheule,

Ulrich Schotten,

Larissa Fabritz,

Nigel A. Brown

Publication year - 2011

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.110.958058

Subject(s) - medicine , endocrinology , pitx2 , biology , atrial fibrillation , gene expression , gene , homeobox , genetics

Intergenic variations on chromosome 4q25, close to the PITX2 transcription factor gene, are associated with atrial fibrillation (AF). We therefore tested whether adult hearts express PITX2 and whether variation in expression affects cardiac function.

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