The Effect of Survival Bias on Case-Control Genetic Association Studies of Highly Lethal Diseases | Zendy

Christopher D. Anderson | Zendy; Michael A. Nalls | Zendy; Alessandro Biffi | Zendy; Natalia S. Rost | Zendy; Steven M. Greenberg | Zendy; Andrew Singleton | Zendy; James F. Meschia | Zendy; Jonathan Rosand | Zendy

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The Effect of Survival Bias on Case-Control Genetic Association Studies of Highly Lethal Diseases

Author(s) -

Christopher D. Anderson,

Michael A. Nalls,

Alessandro Biffi,

Natalia S. Rost,

Steven M. Greenberg,

Andrew Singleton,

James F. Meschia,

Jonathan Rosand

Publication year - 2011

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.110.957928

Subject(s) - association (psychology) , genetic association , biology , control (management) , genetics , medicine , genotype , psychology , single nucleotide polymorphism , computer science , gene , artificial intelligence , psychotherapist

Survival bias is the phenomenon by which individuals are excluded from analysis of a trait because of mortality related to the expression of that trait. In genetic association studies, variants increasing risk for disease onset as well as risk of disease-related mortality (lethality) could be difficult to detect in genetic association case-control designs, possibly leading to underestimation of a variant's effect on disease risk.

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