Reciprocal Transcriptional Regulation of Metabolic and Signaling Pathways Correlates With Disease Severity in Heart Failure | Zendy

Andreas S. Barth | Zendy; Ami Kumordzie | Zendy; Constantine Frangakis | Zendy; Kenneth B. Margulies | Zendy; Thomas P. Cappola | Zendy; Gordon F. Tomaselli | Zendy

Open Access

Reciprocal Transcriptional Regulation of Metabolic and Signaling Pathways Correlates With Disease Severity in Heart Failure

Author(s) -

Andreas S. Barth,

Ami Kumordzie,

Constantine Frangakis,

Kenneth B. Margulies,

Thomas P. Cappola,

Gordon F. Tomaselli

Publication year - 2011

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.110.957571

Subject(s) - downregulation and upregulation , biology , microarray analysis techniques , gene expression , biological pathway , signal transduction , heart failure , microarray , regulation of gene expression , gene expression profiling , endocrinology , medicine , gene , microbiology and biotechnology , genetics

Systolic heart failure (HF) is a complex systemic syndrome that can result from a wide variety of clinical conditions and gene mutations. Despite phenotypic similarities, characterized by ventricular dilatation and reduced contractility, the extent of common and divergent gene expression between different forms of HF remains a matter of intense debate.

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