Gain-of-Function Mutations in TRPM4 Cause Autosomal Dominant Isolated Cardiac Conduction Disease | Zendy

Hui Liu | Zendy; Loubna El Zein | Zendy; Martin Kruse | Zendy; Romain Guinamard | Zendy; Alf Beckmann | Zendy; A Bozio | Zendy; Güven Kurtbay | Zendy; André Mégarbané | Zendy; Iris Ohmert | Zendy; G Blaysat | Zendy; E Villain | Zendy; Olaf Pongs | Zendy; Patrice Bouvagnet | Zendy

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Gain-of-Function Mutations in TRPM4 Cause Autosomal Dominant Isolated Cardiac Conduction Disease

Author(s) -

Hui Liu,

Loubna El Zein,

Martin Kruse,

Romain Guinamard,

Alf Beckmann,

A Bozio,

Güven Kurtbay,

André Mégarbané,

Iris Ohmert,

G Blaysat,

E Villain,

Olaf Pongs,

Patrice Bouvagnet

Publication year - 2010

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.109.930867

Subject(s) - disease , gain of function , genetics , medicine , mutation , genotype , cardiology , biology , gene

Isolated cardiac conduction block is a relatively common condition in young and elderly populations. Genetic predisposing factors have long been suspected because of numerous familial case reports. Deciphering genetic predisposing factors of conduction blocks may give a hint at stratifying conduction block carriers in a more efficient way.

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