Open AccessA Common Variant at Chromosome 9P21.3 Is Associated With Age of Onset of Coronary Disease but Not Subsequent Mortality
Author(s) -
Katrina L. Ellis,
Anna P. Pilbrow,
Chris Frampton,
Robert N. Doughty,
Gillian Whalley,
Chris Ellis,
Barry R. Palmer,
Lorraine Skelton,
Timothy G. Yandle,
Suetonia C. Palmer,
Richard W. Troughton,
Mark Richards,
Vicky A. Cameron
Publication year - 2010
Publication title -
circulation cardiovascular genetics
Language(s) - English
Resource type - Journals
eISSN - 1942-3268
pISSN - 1942-325X
DOI - 10.1161/circgenetics.109.917443
Subject(s) - medicine , myocardial infarction , coronary artery disease , angina , cardiology , cohort , proportional hazards model , genotype , disease , percutaneous coronary intervention , unstable angina , coronary atherosclerosis , genetics , biology , gene
Chromosome 9p21.3 (chr9p21.3) recently was identified by several genome-wide association studies as the genomic region most strongly associated with the risk of coronary artery disease. Within the chr9p21.3 locus, the single-nucleotide polymorphism rs1333049 has been demonstrated to be most strongly associated with susceptibility to developing coronary artery disease. However, the effect of rs1333049 on clinical outcomes in patients with established coronary disease has yet to be determined.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom