Heart Failure–Associated Changes in RNA Splicing of Sarcomere Genes | Zendy

Sek Won Kong | Zendy; Yong Hu | Zendy; Joshua W. K. Ho | Zendy; Sadakatsu Ikeda | Zendy; Sean P. Polster | Zendy; Ranjit John | Zendy; Jennifer L. Hall | Zendy; Egbert Bisping | Zendy; Burkert Pieske | Zendy; Cristobal G. dos Remedios | Zendy; William T. Pu | Zendy

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Heart Failure–Associated Changes in RNA Splicing of Sarcomere Genes

Author(s) -

Sek Won Kong,

Yong Hu,

Joshua W. K. Ho,

Sadakatsu Ikeda,

Sean P. Polster,

Ranjit John,

Jennifer L. Hall,

Egbert Bisping,

Burkert Pieske,

Cristobal G. dos Remedios,

William T. Pu

Publication year - 2010

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.109.904698

Subject(s) - rna splicing , biology , exon , alternative splicing , intron , spliceosome , medicine , gene , genetics , rna

Alternative mRNA splicing is an important mechanism for regulation of gene expression. Altered mRNA splicing occurs in association with several types of cancer, and a small number of disease-associated changes in splicing have been reported in heart disease. However, genome-wide approaches have not been used to study splicing changes in heart disease. We hypothesized that mRNA splicing is different in diseased hearts compared with control hearts.

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