Genetic Association of the CCR5 Region With Lipid Levels in At-Risk Cardiovascular Patients | Zendy

Craig Hyde | Zendy; Alan MacInnes | Zendy; Frances Sanders | Zendy; John F. Thompson | Zendy; Richard Mazzarella | Zendy; Ole Færgeman | Zendy; Diederik F. van Wijk | Zendy; Linda S. Wood | Zendy; M. Gomez Lira | Zendy; Sara A. Paciga | Zendy

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Genetic Association of the CCR5 Region With Lipid Levels in At-Risk Cardiovascular Patients

Author(s) -

Craig Hyde,

Alan MacInnes,

Frances Sanders,

John F. Thompson,

Richard Mazzarella,

Ole Færgeman,

Diederik F. van Wijk,

Linda S. Wood,

M. Gomez Lira,

Sara A. Paciga

Publication year - 2010

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.109.897793

Subject(s) - biology , linkage disequilibrium , genome wide association study , genetics , single nucleotide polymorphism , locus (genetics) , atorvastatin , medicine , endocrinology , genotype , gene

There is mounting evidence to suggest that chemokine receptor 5 (CCR5) plays an important role in the development and progression of atherosclerosis. A naturally occurring variant of the CCR5 gene CCR532, exists at allele frequencies of typically 10% in European populations and results in a nonfunctional CCR5 receptor.

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