Genomic Variation Associated With Mortality Among Adults of European and African Ancestry With Heart Failure | Zendy

Alanna C. Morrison | Zendy; Janine F. Felix | Zendy; L. Adrienne Cupples | Zendy; Nicole L. Glazer | Zendy; Laura R. Loehr | Zendy; Abbas Dehghan | Zendy; Serkalem Demissie | Zendy; Joshua C. Bis | Zendy; Wayne D. Rosamond | Zendy; Yurii S. Aulchenko | Zendy; Ying A. Wang | Zendy; Talin Haritunians | Zendy; Aaron R. Folsom | Zendy; Fernando Rivadeneira | Zendy; Emelia J. Benjamin | Zendy; Thomas Lumley | Zendy; David Couper | Zendy; Bruno H. Stricker | Zendy; Christopher J O’Donnell | Zendy; Kenneth Rice | Zendy; Patricia P. Chang | Zendy; Albert Hofman | Zendy; Daniel Levy | Zendy; Jerome I. Rotter | Zendy; Ervin R. Fox | Zendy; André G. Uitterlinden | Zendy; Thomas J. Wang | Zendy; Bruce M. Psaty | Zendy; James T. Willerson | Zendy; Cornelia M. van Duijn | Zendy; Eric Boerwinkle | Zendy; Jacqueline C.M. Witteman | Zendy; Ramachandran S. Vasan | Zendy; Nicholas L. Smith | Zendy

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Genomic Variation Associated With Mortality Among Adults of European and African Ancestry With Heart Failure

Author(s) -

Alanna C. Morrison,

Janine F. Felix,

L. Adrienne Cupples,

Nicole L. Glazer,

Laura R. Loehr,

Abbas Dehghan,

Serkalem Demissie,

Joshua C. Bis,

Wayne D. Rosamond,

Yurii S. Aulchenko,

Ying A. Wang,

Talin Haritunians,

Aaron R. Folsom,

Fernando Rivadeneira,

Emelia J. Benjamin,

Thomas Lumley,

David Couper,

Bruno H. Stricker,

Christopher J O’Donnell,

Kenneth Rice,

Patricia P. Chang,

Albert Hofman,

Daniel Levy,

Jerome I. Rotter,

Ervin R. Fox,

André G. Uitterlinden,

Thomas J. Wang,

Bruce M. Psaty,

James T. Willerson,

Cornelia M. van Duijn,

Eric Boerwinkle,

Jacqueline C.M. Witteman,

Ramachandran S. Vasan,

Nicholas L. Smith

Publication year - 2010

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.109.895995

Subject(s) - single nucleotide polymorphism , framingham heart study , ancestry informative marker , genome wide association study , proportional hazards model , hazard ratio , genetic genealogy , locus (genetics) , medicine , minor allele frequency , prospective cohort study , genetics , demography , disease , biology , framingham risk score , genotype , population , confidence interval , gene , environmental health , sociology

Prognosis and survival are significant concerns for individuals with heart failure (HF). To better understand the pathophysiology of HF prognosis, the association between 2,366,858 single-nucleotide polymorphisms (SNPs) and all-cause mortality was evaluated among individuals with incident HF from 4 community-based prospective cohorts: the Atherosclerosis Risk in Communities Study, the Cardiovascular Health Study, the Framingham Heart Study, and the Rotterdam Study.

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