Association of Genome-Wide Variation With the Risk of Incident Heart Failure in Adults of European and African Ancestry | Zendy

Nicholas L. Smith | Zendy; Janine F. Felix | Zendy; Alanna C. Morrison | Zendy; Serkalem Demissie | Zendy; Nicole L. Glazer | Zendy; Laura R. Loehr | Zendy; L. Adrienne Cupples | Zendy; Abbas Dehghan | Zendy; Thomas Lumley | Zendy; Wayne D. Rosamond | Zendy; Wolfgang Lieb | Zendy; Fernando Rivadeneira | Zendy; Joshua C. Bis | Zendy; Aaron R. Folsom | Zendy; Emelia J. Benjamin | Zendy; Yurii S. Aulchenko | Zendy; Talin Haritunians | Zendy; David Couper | Zendy; Joanne M. Murabito | Zendy; Ying A. Wang | Zendy; Bruno H. Stricker | Zendy; John S. Gottdiener | Zendy; Patricia P. Chang | Zendy; Thomas J. Wang | Zendy; Kenneth Rice | Zendy; Albert Hofman | Zendy; Susan R. Heckbert | Zendy; Ervin R. Fox | Zendy; Christopher J. O’Donnell | Zendy; André G. Uitterlinden | Zendy; Jerome I. Rotter | Zendy; James T. Willerson | Zendy; Daniel Levy | Zendy; Cornelia M. van Duijn | Zendy; Bruce M. Psaty | Zendy; Jacqueline C.M. Witteman | Zendy; Eric Boerwinkle | Zendy; Ramachandran S. Vasan | Zendy

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Association of Genome-Wide Variation With the Risk of Incident Heart Failure in Adults of European and African Ancestry

Author(s) -

Nicholas L. Smith,

Janine F. Felix,

Alanna C. Morrison,

Serkalem Demissie,

Nicole L. Glazer,

Laura R. Loehr,

L. Adrienne Cupples,

Abbas Dehghan,

Thomas Lumley,

Wayne D. Rosamond,

Wolfgang Lieb,

Fernando Rivadeneira,

Joshua C. Bis,

Aaron R. Folsom,

Emelia J. Benjamin,

Yurii S. Aulchenko,

Talin Haritunians,

David Couper,

Joanne M. Murabito,

Ying A. Wang,

Bruno H. Stricker,

John S. Gottdiener,

Patricia P. Chang,

Thomas J. Wang,

Kenneth Rice,

Albert Hofman,

Susan R. Heckbert,

Ervin R. Fox,

Christopher J. O’Donnell,

André G. Uitterlinden,

Jerome I. Rotter,

James T. Willerson,

Daniel Levy,

Cornelia M. van Duijn,

Bruce M. Psaty,

Jacqueline C.M. Witteman,

Eric Boerwinkle,

Ramachandran S. Vasan

Publication year - 2010

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.109.895763

Subject(s) - international hapmap project , framingham heart study , genome wide association study , single nucleotide polymorphism , proportional hazards model , rotterdam study , medicine , minor allele frequency , locus (genetics) , genetics , framingham risk score , prospective cohort study , demography , biology , disease , genotype , gene , sociology

Although genetic factors contribute to the onset of heart failure (HF), no large-scale genome-wide investigation of HF risk has been published to date. We have investigated the association of 2,478,304 single-nucleotide polymorphisms with incident HF by meta-analyzing data from 4 community-based prospective cohorts: the Atherosclerosis Risk in Communities Study, the Cardiovascular Health Study, the Framingham Heart Study, and the Rotterdam Study.

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