A Locus Mapping to Mouse Chromosome 7 Determines Infarct Volume in a Mouse Model of Ischemic Stroke | Zendy

Sehoon Keum | Zendy; Douglas A. Marchuk | Zendy

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A Locus Mapping to Mouse Chromosome 7 Determines Infarct Volume in a Mouse Model of Ischemic Stroke

Author(s) -

Sehoon Keum,

Douglas A. Marchuk

Publication year - 2009

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.109.883231

Subject(s) - locus (genetics) , ischemic stroke , stroke (engine) , biology , genetics , medicine , cardiology , gene , ischemia , mechanical engineering , engineering

In a mouse model of focal cerebral ischemia, infarct volume is highly variable and strain dependent, but the natural genetic determinants responsible for this difference remain unknown. To identify genetic determinants regulating ischemic neuronal damage and to dissect apart the role of individual genes and physiological mechanisms in infarction in mice, we performed quantitative trait locus analysis of surgically induced cerebral infarct volume.

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