Echocardiographic Strain Imaging to Assess Early and Late Consequences of Sarcomere Mutations in Hypertrophic Cardiomyopathy | Zendy

Carolyn Y. Ho | Zendy; Christian Malchau Carlsen | Zendy; Jens Jakob Thune | Zendy; Ole Havndrup | Zendy; Henning Bundgaard | Zendy; Faranak Farrohi | Zendy; Jose Rivero | Zendy; Allison L. Cirino | Zendy; Paal Skytt Andersen | Zendy; Michael Christiansen | Zendy; Barry J. Maron | Zendy; E. John Orav | Zendy; Lars K⊘ber | Zendy

Open Access

Echocardiographic Strain Imaging to Assess Early and Late Consequences of Sarcomere Mutations in Hypertrophic Cardiomyopathy

Author(s) -

Carolyn Y. Ho,

Christian Malchau Carlsen,

Jens Jakob Thune,

Ole Havndrup,

Henning Bundgaard,

Faranak Farrohi,

Jose Rivero,

Allison L. Cirino,

Paal Skytt Andersen,

Michael Christiansen,

Barry J. Maron,

E. John Orav,

Lars K⊘ber

Publication year - 2009

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.109.862128

Subject(s) - hypertrophic cardiomyopathy , sarcomere , cardiology , medicine , ejection fraction , diastole , left ventricular hypertrophy , muscle hypertrophy , cardiomyopathy , heart failure , blood pressure , myocyte

Genetic testing identifies sarcomere mutation carriers (G+) before clinical diagnosis of hypertrophic cardiomyopathy (HCM), allowing characterization of initial disease manifestations. Previous studies demonstrated that impaired relaxation develops before left ventricular hypertrophy (LVH). The precise impact of sarcomere mutations on systolic function in early and late disease is unclear.

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