Plasma Bilirubin and UGT1A1*28 Are Not Protective Factors Against First-Time Myocardial Infarction in a Prospective, Nested Case–Referent Setting | Zendy

Kim Ekblom | Zendy; Stefan L. Marklund | Zendy; JanHåkan Jansson | Zendy; Pia Osterman | Zendy; Göran Hallmans | Zendy; Lars Weinehall | Zendy; Johan Hultdin | Zendy

Open Access

Plasma Bilirubin and UGT1A1*28 Are Not Protective Factors Against First-Time Myocardial Infarction in a Prospective, Nested Case–Referent Setting

Author(s) -

Kim Ekblom,

Stefan L. Marklund,

JanHåkan Jansson,

Pia Osterman,

Göran Hallmans,

Lars Weinehall,

Johan Hultdin

Publication year - 2010

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.109.861773

Subject(s) - myocardial infarction , bilirubin , medicine , prospective cohort study , referent , glucuronosyltransferase , cardiology , gastroenterology , endocrinology , biochemistry , enzyme , chemistry , microsome , philosophy , linguistics

Bilirubin, an effective antioxidant, shows a large variation in levels between individuals and has been positively associated with reduced cardiovascular disease risk. A major reason for the variability is a common promoter polymorphism, UGT1A1*28, which reduces the transcription of the enzyme that conjugates bilirubin, UDP-glucuronosyltransferase 1A1. The aim of the study was to evaluate a possible protective effect of plasma bilirubin and the UGT1A1*28 polymorphism against myocardial infarction in a prospective case-referent setting.

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