A Common Copy Number Variation on Chromosome 6 Association With the Gene Expression Level of Endothelin 1 in Transformed B Lymphocytes From Three Racial Groups | Zendy

Yan V. Sun | Zendy; Patricia A. Peyser | Zendy; Sharon L. R. Kardia | Zendy

Open Access

A Common Copy Number Variation on Chromosome 6 Association With the Gene Expression Level of Endothelin 1 in Transformed B Lymphocytes From Three Racial Groups

Author(s) -

Yan V. Sun,

Patricia A. Peyser,

Sharon L. R. Kardia

Publication year - 2009

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.109.848754

Subject(s) - copy number variation , international hapmap project , biology , genetics , single nucleotide polymorphism , genetic association , gene , genetic variation , genome , genotype

Previous studies indicate that the endothelin system is involved in hypertension, heart failure, atherosclerosis, chronic kidney disease, and diabetes. To explore the potential genetic effects of copy number variations (CNVs) on the endothelin system, which underlie these diseases, we studied the association of genome-wide CNVs with gene expression levels of 7 genes involved in the endothelin system using independent HapMap subjects including 90 Asians (45 Han Chinese and 45 Japanese), 60 whites, and 60 blacks.

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