In Vivo Genetic Evidence for Suppressing Vascular and Soft-Tissue Calcification Through the Reduction of Serum Phosphate Levels, Even in the Presence of High Serum Calcium and 1,25-Dihydroxyvitamin D Levels | Zendy

Mutsuko Ohnishi | Zendy; Teruyo Nakatani | Zendy; Beate Lanske | Zendy; Mohammed S. Razzaque | Zendy

Open Access

In Vivo Genetic Evidence for Suppressing Vascular and Soft-Tissue Calcification Through the Reduction of Serum Phosphate Levels, Even in the Presence of High Serum Calcium and 1,25-Dihydroxyvitamin D Levels

Author(s) -

Mutsuko Ohnishi,

Teruyo Nakatani,

Beate Lanske,

Mohammed S. Razzaque

Publication year - 2009

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.108.847814

Subject(s) - hyperphosphatemia , klotho , endocrinology , medicine , calcification , hypophosphatemia , fibroblast growth factor 23 , knockout mouse , kidney , vascular tissue , calcium , biology , parathyroid hormone , receptor , botany

Klotho-knockout mice (klotho(-/-)) have increased renal expression of sodium/phosphate cotransporters (NaPi2a), associated with severe hyperphosphatemia. Such serum biochemical changes in klotho(-/-) mice lead to extensive soft-tissue anomalies and vascular calcification. To determine the significance of increased renal expression of the NaPi2a protein and concomitant hyperphosphatemia and vascular calcification in klotho(-/-) mice, we generated klotho and NaPi2a double-knockout (klotho(-/-)/NaPi2a(-/-)) mice.

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