Novel Associations of CPS1, MUT, NOX4, and DPEP1 With Plasma Homocysteine in a Healthy Population | Zendy

Guillaume Paré | Zendy; Daniel I. Chasman | Zendy; Alexander N. Parker | Zendy; Robert R.Y. Zee | Zendy; Anders Mälarstig | Zendy; Udo Seedorf | Zendy; Rory Collins | Zendy; Hugh Watkins | Zendy; Anders Hamsten | Zendy; Joseph P. Miletich | Zendy; Paul M. Ridker | Zendy

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Novel Associations of CPS1, MUT, NOX4, and DPEP1 With Plasma Homocysteine in a Healthy Population

Author(s) -

Guillaume Paré,

Daniel I. Chasman,

Alexander N. Parker,

Robert R.Y. Zee,

Anders Mälarstig,

Udo Seedorf,

Rory Collins,

Hugh Watkins,

Anders Hamsten,

Joseph P. Miletich,

Paul M. Ridker

Publication year - 2009

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.108.829804

Subject(s) - methylenetetrahydrofolate reductase , homocysteine , single nucleotide polymorphism , genome wide association study , genetic association , biology , medicine , genetics , bioinformatics , genotype , gene

Homocysteine is a sulfur amino acid whose plasma concentration has been associated with the risk of cardiovascular diseases, neural tube defects, and loss of cognitive function in epidemiological studies. Although genetic variants of MTHFR and CBS are known to influence homocysteine concentration, common genetic determinants of homocysteine remain largely unknown.

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