Low Incidence of Sudden Cardiac Death in a Swedish Y111C Type 1 Long-QT syndrome Population | Zendy

Annika Winbo | Zendy; UllaBritt Diamant | Zendy; EvaLena Stattin | Zendy; Steen M. Jensen | Zendy; Annika Rydberg | Zendy

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Low Incidence of Sudden Cardiac Death in a Swedish Y111C Type 1 Long-QT syndrome Population

Author(s) -

Annika Winbo,

UllaBritt Diamant,

EvaLena Stattin,

Steen M. Jensen,

Annika Rydberg

Publication year - 2009

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.108.825547

Subject(s) - long qt syndrome , sudden cardiac death , incidence (geometry) , cardiology , medicine , sudden death , population , qt interval , physics , environmental health , optics

A 10% cumulative incidence and a 0.3% per year incidence rate of sudden cardiac death in patients younger than 40 years and without therapy have been reported in type 1 long-QT syndrome. The Y111C-KCNQ1 mutation causes a severe phenotype in vitro, suggesting a high-risk mutation. This study investigated the phenotype among Y111C-KCNQ1 mutation carriers in the Swedish population with a focus on life-threatening cardiac events.

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