Refining Molecular Pathways Leading to Calcific Aortic Valve Stenosis by Studying Gene Expression Profile of Normal and Calcified Stenotic Human Aortic Valves | Zendy

Yohan Bossé | Zendy; Ahmed Miqdad | Zendy; Dominique Fournier | Zendy; Andrée Pépin | Zendy; Philippe Pîbarot | Zendy; Patrick Mathieu | Zendy

Open Access

Refining Molecular Pathways Leading to Calcific Aortic Valve Stenosis by Studying Gene Expression Profile of Normal and Calcified Stenotic Human Aortic Valves

Author(s) -

Yohan Bossé,

Ahmed Miqdad,

Dominique Fournier,

Andrée Pépin,

Philippe Pîbarot,

Patrick Mathieu

Publication year - 2009

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.108.820795

Subject(s) - pathogenesis , microarray , gene , microarray analysis techniques , aortic valve , population , gene expression , candidate gene , biological pathway , biology , gene expression profiling , genetics , bioinformatics , pathology , medicine , environmental health

Calcific aortic valve stenosis (AS) is a major societal and economic burden that is rising after the current shift toward an older population. Understanding the pathobiology of AS is crucial to implementing better preventive and therapeutic options. Research conducted during the past decade clearly points to active molecular and cellular processes involved in disease pathogenesis. However, no genomic approaches were used to identify genes and pathways that are differentially regulated in aortic valves of patients with and without AS.

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