Comprehensive Whole-Genome and Candidate Gene Analysis for Response to Statin Therapy in the Treating to New Targets (TNT) Cohort | Zendy

John F. Thompson | Zendy; Craig Hyde | Zendy; Linda S. Wood | Zendy; Sara A. Paciga | Zendy; David A. Hinds | Zendy; David R. Cox | Zendy; G. Kees Hovingh | Zendy; John J.P. Kastelein | Zendy

Open Access

Comprehensive Whole-Genome and Candidate Gene Analysis for Response to Statin Therapy in the Treating to New Targets (TNT) Cohort

Author(s) -

John F. Thompson,

Craig Hyde,

Linda S. Wood,

Sara A. Paciga,

David A. Hinds,

David R. Cox,

G. Kees Hovingh,

John J.P. Kastelein

Publication year - 2009

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.108.818062

Subject(s) - single nucleotide polymorphism , genome wide association study , atorvastatin , pcsk9 , candidate gene , genotyping , biology , statin , genetics , genetic association , population , cholesterol , bioinformatics , medicine , lipoprotein , gene , genotype , endocrinology , ldl receptor , environmental health

Statins are effective at lowering low-density lipoprotein cholesterol and reducing risk of cardiovascular disease, but variability in response is not well understood. To address this, 5745 individuals from the Treating to New Targets (TNT) trial were genotyped in a combination of a whole-genome and candidate gene approach to identify associations with response to atorvastatin treatment.

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