Polymorphism in the CETP Gene Region, HDL Cholesterol, and Risk of Future Myocardial Infarction | Zendy

Paul M. Ridker | Zendy; Guillaume Paré | Zendy; Alex Parker | Zendy; Robert Y.L. Zee | Zendy; Joseph P. Miletich | Zendy; Daniel I. Chasman | Zendy

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Polymorphism in the CETP Gene Region, HDL Cholesterol, and Risk of Future Myocardial Infarction

Author(s) -

Paul M. Ridker,

Guillaume Paré,

Alex Parker,

Robert Y.L. Zee,

Joseph P. Miletich,

Daniel I. Chasman

Publication year - 2009

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.108.817304

Subject(s) - cholesterylester transfer protein , myocardial infarction , single nucleotide polymorphism , medicine , hazard ratio , genome wide association study , prospective cohort study , snp , cholesterol , cardiology , endocrinology , lipoprotein , genetics , biology , gene , genotype , confidence interval

Recent trial data have challenged the hypothesis that cholesteryl ester transfer protein (CETP) and high-density lipoprotein cholesterol (HDL-C) have causal roles in atherothrombosis. One method to evaluate this issue is to examine whether polymorphisms in the CETP gene that impact on HDL-C levels also impact on the future development of myocardial infarction.

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