Evidence for Coregulation of Myocardial Gene Expression by MEF2 and NFAT in Human Heart Failure | Zendy

Mary Putt | Zendy; Sridhar Hannenhalli | Zendy; Yun Lu | Zendy; Philip Haines | Zendy; Hareesh Chandrupatla | Zendy; Edward E. Morrisey | Zendy; Kenneth B. Margulies | Zendy; Thomas P. Cappola | Zendy

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Evidence for Coregulation of Myocardial Gene Expression by MEF2 and NFAT in Human Heart Failure

Author(s) -

Mary Putt,

Sridhar Hannenhalli,

Yun Lu,

Philip Haines,

Hareesh Chandrupatla,

Edward E. Morrisey,

Kenneth B. Margulies,

Thomas P. Cappola

Publication year - 2009

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.108.816686

Subject(s) - nfat , mef2 , biology , promoter , gene , genetics , gene expression , transcription factor , gene regulatory network , enhancer , regulation of gene expression , regulatory sequence

Pathological stresses induce heart failure in animal models through activation of multiple cardiac transcription factors (TFs) working cooperatively. However, interactions among TFs in human heart failure are less understood. Here, we use genomic data to examine the evidence that 5 candidate TF families coregulate gene expression in human heart failure.

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