Open Access9p21 is a Shared Susceptibility Locus Strongly for Coronary Artery Disease and Weakly for Ischemic Stroke in Chinese Han Population
Author(s) -
Hu Ding,
Yujun Xu,
Xiaojing Wang,
Qi Wang,
Lan Zhang,
Yuanchao Tu,
Jiangtao Yan,
Wei Wang,
Rutai Hui,
CongYi Wang,
Dao Wen Wang
Publication year - 2009
Publication title -
circulation cardiovascular genetics
Language(s) - English
Resource type - Journals
eISSN - 1942-325X
pISSN - 1942-3268
DOI - 10.1161/circgenetics.108.810226
Subject(s) - haplotype , single nucleotide polymorphism , coronary artery disease , medicine , locus (genetics) , ischemic stroke , case control study , population , stroke (engine) , genetics , snp , cardiology , bioinformatics , biology , genotype , ischemia , gene , mechanical engineering , environmental health , engineering
Recent studies on genome-wide association have identified common variants on chromosome 9p21 associated with coronary artery disease (CAD). Given that ischemic stroke and CAD share several aspects of etiology and pathogenesis, we investigated the association of variants on chromosome 9p21 with ischemic stroke and CAD in the Chinese Han population by capturing the majority of diversity in this locus using haplotype-tagging single-nucleotide polymorphisms.
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