Genome-Wide Identification of Allelic Expression in Hypertensive Rats | Zendy

Renata I. Dmitrieva | Zendy; Cruz A. Hinojos | Zendy; Megan L. Grove | Zendy; Rebecca Bell | Zendy; Eric Boerwinkle | Zendy; Myriam Fornage | Zendy; Peter A. Doris | Zendy

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Genome-Wide Identification of Allelic Expression in Hypertensive Rats

Author(s) -

Renata I. Dmitrieva,

Cruz A. Hinojos,

Megan L. Grove,

Rebecca Bell,

Eric Boerwinkle,

Myriam Fornage,

Peter A. Doris

Publication year - 2009

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.108.809509

Subject(s) - allele , gene , biology , genetics , phenotype , spontaneously hypertensive rat , gene expression , inbred strain , candidate gene , genetic variation , quantitative trait locus , gene expression profiling , endocrinology , blood pressure

Identification of genes involved in complex cardiovascular disease traits has proven challenging. Inbred animal models can facilitate genetic studies of disease traits. The spontaneously hypertensive rat (SHR) is an inbred model of hypertension that exists in several closely related but genetically distinct lines.

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