Time-Warped Comparison of Gene Expression in Adaptive and Maladaptive Cardiac Hypertrophy | Zendy

Sean P. Sheehy | Zendy; Sui Huang | Zendy; Kevin Kit Parker | Zendy

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Time-Warped Comparison of Gene Expression in Adaptive and Maladaptive Cardiac Hypertrophy

Author(s) -

Sean P. Sheehy,

Sui Huang,

Kevin Kit Parker

Publication year - 2009

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.108.806935

Subject(s) - muscle hypertrophy , gene expression , fibrosis , transcriptome , biology , pressure overload , stimulus (psychology) , gene , pathological , medicine , gene expression profiling , endocrinology , genetics , cardiac hypertrophy , psychology , psychotherapist

Cardiac hypertrophy is classically regarded as a compensatory response, yet the active tissue remodeling processes triggered by various types of mechanical stress can enhance or diminish the function of the heart. Despite the disparity in outcomes, there are similarities in the hypertrophic responses. We hypothesized that a generic genetic response that is not dependent on the particular nature of the hypertrophic stimulus exists. To test our hypothesis, we compared the temporal evolution of transcriptomes measured in hearts subjected to either adaptive (exercise-induced) or maladaptive (aortic banding-induced) hypertrophy.

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