Hypophosphatemia, Hyperphosphaturia, and Bisphosphonate Treatment Are Associated With Survival Beyond Infancy in Generalized Arterial Calcification of Infancy | Zendy

Frank Rutsch | Zendy; Petra Böyer | Zendy; Yvonne Nitschke | Zendy; Nico Ruf | Zendy; Bettina Lorenz-Depierieux | Zendy; Tanja Wittkampf | Zendy; Gabriele Weißen-Plenz | Zendy; RudolfJosef Fischer | Zendy; Zulf Mughal | Zendy; John W. Gregory | Zendy; Justin H. Davies | Zendy; Chantal Loirat | Zendy; Tim M. Strom | Zendy; Dirk Schnabel | Zendy; Peter Nürnberg | Zendy; Robert Terkeltaub | Zendy

Open Access

Hypophosphatemia, Hyperphosphaturia, and Bisphosphonate Treatment Are Associated With Survival Beyond Infancy in Generalized Arterial Calcification of Infancy

Author(s) -

Frank Rutsch,

Petra Böyer,

Yvonne Nitschke,

Nico Ruf,

Bettina Lorenz-Depierieux,

Tanja Wittkampf,

Gabriele Weißen-Plenz,

RudolfJosef Fischer,

Zulf Mughal,

John W. Gregory,

Justin H. Davies,

Chantal Loirat,

Tim M. Strom,

Dirk Schnabel,

Peter Nürnberg,

Robert Terkeltaub

Publication year - 2008

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.108.797704

Subject(s) - hypophosphatemia , medicine , compound heterozygosity , calcification , gastroenterology , rickets , pediatrics , allele , vitamin d and neurology , genetics , biology , gene

Generalized arterial calcification of infancy has been reported to be frequently lethal, and the efficiency of any therapy, including bisphosphonates, is unknown. A phosphate-poor diet markedly increases survival of NPP1 null mice, a model of generalized arterial calcification of infancy.

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