Variants of Folate Metabolism Genes and the Risk of Conotruncal Cardiac Defects | Zendy

Elizabeth Goldmuntz | Zendy; Stacy Woyciechowski | Zendy; Daniel Renstrom | Zendy; Philip J. Lupo | Zendy; Laura E. Mitchell | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Variants of Folate Metabolism Genes and the Risk of Conotruncal Cardiac Defects

Author(s) -

Elizabeth Goldmuntz,

Stacy Woyciechowski,

Daniel Renstrom,

Philip J. Lupo,

Laura E. Mitchell

Publication year - 2008

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.108.796342

Subject(s) - neural tube , methylenetetrahydrofolate reductase , phenotype , biology , gene , genetics , genotype , cohort , heart disease , medicine , physiology , embryo

Although congenital heart defects (CHD) are the most common and serious group of birth defects, relatively little is known about the causes of these conditions and there are no established prevention strategies. There is evidence suggesting that the risk of CHD in general, and conotruncal and ventricular septal defects in particular, may be related to maternal folate status as well as genetic variants in folate-related genes. However, efforts to establish the relationships between these factors and CHD risk have been hampered by a number of factors including small study sample sizes and phenotypic heterogeneity.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research