Mutations in the HFE Gene and Cardiovascular Disease Risk | Zendy

Daphne L. van der A | Zendy; Maroeska M. Rovers | Zendy; Diederick E. Grobbee | Zendy; Joannes J.M. Marx | Zendy; Jill Waalen | Zendy; Christina Ellervik | Zendy; Børge G. Nordestgaard | Zendy; John K. Olynyk | Zendy; Peter R. Mills | Zendy; James Shepherd | Zendy; Bernard Grandchamp | Zendy; Jolanda M.A. Boer | Zendy; Calogero Caruso | Zendy; Marcello Arca | Zendy; Beat J. Meyer | Zendy; Yvonne T. van der Schouw | Zendy

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Mutations in the HFE Gene and Cardiovascular Disease Risk

Author(s) -

Daphne L. van der A,

Maroeska M. Rovers,

Diederick E. Grobbee,

Joannes J.M. Marx,

Jill Waalen,

Christina Ellervik,

Børge G. Nordestgaard,

John K. Olynyk,

Peter R. Mills,

James Shepherd,

Bernard Grandchamp,

Jolanda M.A. Boer,

Calogero Caruso,

Marcello Arca,

Beat J. Meyer,

Yvonne T. van der Schouw

Publication year - 2008

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.108.773176

Subject(s) - odds ratio , medicine , hereditary hemochromatosis , genotype , myocardial infarction , hemochromatosis , genetics , biology , gene

Whether mutations in the hemochromatosis (HFE) gene increase cardiovascular disease risk is still undetermined. The main reason is the low frequency of the mutations, in particular of the compound C282Y/H63D genotype. We combined the data of 11 observational studies for an individual patient data meta-analysis.

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