Effects of Late Sodium Current Blockade on Ventricular Refibrillation in a Rabbit Model | Zendy

Mohammed Ali Azam | Zendy; Nima Zamiri | Zendy; Stéphane Massé | Zendy; M. Kusha | Zendy; Patrick F.H. Lai | Zendy; Govind Krishna Kumar Nair | Zendy; Nigel S. Tan | Zendy; Christopher Labos | Zendy; Kumaraswamy Nanthakumar | Zendy

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Effects of Late Sodium Current Blockade on Ventricular Refibrillation in a Rabbit Model

Author(s) -

Mohammed Ali Azam,

Nima Zamiri,

Stéphane Massé,

M. Kusha,

Patrick F.H. Lai,

Govind Krishna Kumar Nair,

Nigel S. Tan,

Christopher Labos,

Kumaraswamy Nanthakumar

Publication year - 2017

Publication title -

circulation arrhythmia and electrophysiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.684

H-Index - 102

eISSN - 1941-3149

pISSN - 1941-3084

DOI - 10.1161/circep.116.004331

Subject(s) - rabbit (cipher) , blockade , sodium , medicine , chemistry , mathematics , receptor , statistics , organic chemistry

After defibrillation of initial ventricular fibrillation (VF), it is crucial to prevent refibrillation to ensure successful resuscitation outcomes. Inability of the late Na + current to inactivate leads to intracellular Ca 2+ dysregulation and arrhythmias. Our aim was to determine the effects of ranolazine and GS-967, inhibitors of the late Na + current, on ventricular refibrillation.

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