Spatial Profiles of Electrical Mismatch Determine Vulnerability to Conduction Failure Across a Host–Donor Cell Interface | Zendy

Robert D. Kirkton | Zendy; Nima Badie | Zendy; Nenad Bursac | Zendy

Open Access

Spatial Profiles of Electrical Mismatch Determine Vulnerability to Conduction Failure Across a Host–Donor Cell Interface

Author(s) -

Robert D. Kirkton,

Nima Badie,

Nenad Bursac

Publication year - 2013

Publication title -

circulation arrhythmia and electrophysiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.684

H-Index - 102

eISSN - 1941-3149

pISSN - 1941-3084

DOI - 10.1161/circep.113.001050

Subject(s) - repolarization , nerve conduction velocity , electrophysiology , coupling (piping) , biophysics , chemistry , sodium channel , stimulation , electrical conduction system of the heart , myocyte , cardiac electrophysiology , thermal conduction , sodium , materials science , medicine , biology , electrocardiography , organic chemistry , metallurgy , composite material

Electrophysiological mismatch between host cardiomyocytes and donor cells can directly affect the electrical safety of cardiac cell therapies; however, the ability to study host-donor interactions at the microscopic scale in situ is severely limited. We systematically explored how action potential (AP) differences between cardiomyocytes and other excitable cells modulate vulnerability to conduction failure in vitro.

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