Role for MicroRNA-21 in Atrial Profibrillatory Fibrotic Remodeling Associated With Experimental Postinfarction Heart Failure | Zendy

Sophie Cardin | Zendy; Eduard Guasch | Zendy; Xiaobin Luo | Zendy; Patrice Naud | Zendy; Khaï Le Quang | Zendy; Yanfen Shi | Zendy; JeanClaude Tardif | Zendy; Philippe Comtois | Zendy; Stanley Nattel | Zendy

Open Access

Role for MicroRNA-21 in Atrial Profibrillatory Fibrotic Remodeling Associated With Experimental Postinfarction Heart Failure

Author(s) -

Sophie Cardin,

Eduard Guasch,

Xiaobin Luo,

Patrice Naud,

Khaï Le Quang,

Yanfen Shi,

JeanClaude Tardif,

Philippe Comtois,

Stanley Nattel

Publication year - 2012

Publication title -

circulation arrhythmia and electrophysiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.684

H-Index - 102

eISSN - 1941-3149

pISSN - 1941-3084

DOI - 10.1161/circep.112.973214

Subject(s) - medicine , heart failure , cardiology , microrna , atrial fibrillation , fibrosis , ventricular remodeling , gene , biochemistry , chemistry

Atrial tissue fibrosis is often an important component of the atrial fibrillation (AF) substrate. Small noncoding microRNAs are important mediators in many cardiac remodeling paradigms. MicroRNA-21 (miR-21) has been suggested to be important in ventricular fibrotic remodeling by downregulating Sprouty-1, a protein that suppresses fibroblast proliferation. The present study examined the potential role of miR-21 in the atrial AF substrate resulting from experimental heart failure after myocardial infarction (MI).

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