Metabolic Modulation | Zendy

Gary D. Lopaschuk | Zendy; Ivan M. Rebeyka | Zendy; Michael F. Allard | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Metabolic Modulation

Author(s) -

Gary D. Lopaschuk,

Ivan M. Rebeyka,

Michael F. Allard

Publication year - 2002

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/circ.105.2.140

Subject(s) - medicine , columbia university , gerontology , university hospital , family medicine , media studies , sociology

featured in this issue of Circulation presents data showingthat pyruvate, which dose-dependently improved perfor-mance in myocardium from failing human hearts, may be onesuch agent.A number of abnormalities in both energy metabolism andcontractile function have been identified in failing cardiacmuscle. Metabolic changes include decreases in high energyphosphorylation potential, decreases in mitochondrial oxida-tive phosphorylation capacity, and a switch to a more fetalglycolytic metabolism.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research