Giant Mitochondria in the Myocardium of a Patient With Mitochondrial Cardiomyopathy | Zendy

Yumiko Kanzaki | Zendy; Fumio Terasaki | Zendy; Makoto Okabe | Zendy; Kaoru Otsuka | Zendy; Takashi Katashima | Zendy; Shuichi Fujita | Zendy; Takahide Ito | Zendy; Yasushi Kitaura | Zendy

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Giant Mitochondria in the Myocardium of a Patient With Mitochondrial Cardiomyopathy

Author(s) -

Yumiko Kanzaki,

Fumio Terasaki,

Makoto Okabe,

Kaoru Otsuka,

Takashi Katashima,

Shuichi Fujita,

Takahide Ito,

Yasushi Kitaura

Publication year - 2010

Publication title -

circulation

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 7.795

H-Index - 607

eISSN - 1524-4539

pISSN - 0009-7322

DOI - 10.1161/cir.0b013e3181d22e2d

Subject(s) - medicine , mitochondrion , cardiomyopathy , cardiology , mitochondrial disease , mitochondrial dna , heart failure , microbiology and biotechnology , genetics , biology , gene

46-year-old man with a clinical diagnosis of dilated phase of hypertrophic cardiomyopathy was followed up at our hospital for 26 years. His refractory congestive heart failure gradually worsened over several years, and he was unresponsive to conventional medications. He then underwent left ventriculoplasty. Biochemical and genetic investigations of the left ventricular myocardium revealed a novel point mutation in the mitochondrial DNA.1Scanning electron microscopy can directly observe both the 3-dimensional structure of a cell with high resolution and the 3-dimensional structure of the membrane system using the osmium-dimethyl sulfoxide-osmium method2 to remove the cytoplasmic matrix. Conventional transmission electron microscopy …

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