Increased Capillary Permeability in Heart Induces Diastolic Dysfunction Independently of Inflammation, Fibrosis, or Cardiomyocyte Dysfunction | Zendy

Alice Abélanet | Zendy; Marion Camoin | Zendy; Sébastien Rubin | Zendy; Pauline Bougaran | Zendy; Valentin Delobel | Zendy; Mathieu Pernot | Zendy; Isabelle Forfar | Zendy; Céline GuilbeauFrugier | Zendy; Céline Galès | Zendy; MarieLise Bats | Zendy; MarieAnge Renault | Zendy; Pascale Dufourcq | Zendy; Thierry Couffinhal | Zendy; Cécile Duplaà | Zendy

Open Access

Increased Capillary Permeability in Heart Induces Diastolic Dysfunction Independently of Inflammation, Fibrosis, or Cardiomyocyte Dysfunction

Author(s) -

Alice Abélanet,

Marion Camoin,

Sébastien Rubin,

Pauline Bougaran,

Valentin Delobel,

Mathieu Pernot,

Isabelle Forfar,

Céline GuilbeauFrugier,

Céline Galès,

MarieLise Bats,

MarieAnge Renault,

Pascale Dufourcq,

Thierry Couffinhal,

Cécile Duplaà

Publication year - 2022

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.121.317319

Subject(s) - heart failure , endothelial dysfunction , medicine , inflammation , fibrosis , diastole , endocrinology , endothelium , ejection fraction , cardiac fibrosis , heart failure with preserved ejection fraction , endothelial activation , blood pressure

While endothelial dysfunction is suggested to contribute to heart failure with preserved ejection fraction pathophysiology, understanding the importance of the endothelium alone, in the pathogenesis of diastolic abnormalities has not yet been fully elucidated. Here, we investigated the consequences of specific endothelial dysfunction on cardiac function, independently of any comorbidity or risk factor (diabetes or obesity) and their potential effect on cardiomyocyte.

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