Role of Platelets in Detection and Regulation of Infection | Zendy

Irina Portier | Zendy; Robert A. Campbell | Zendy

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Role of Platelets in Detection and Regulation of Infection

Author(s) -

Irina Portier,

Robert A. Campbell

Publication year - 2020

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.120.314645

Subject(s) - platelet , hemostasis , immune system , inflammation , immunology , pathogen , platelet activation , biology , thrombosis , medicine

Platelets are classically known as essential mediators of hemostasis and thrombosis. However, in recent years, platelets have gained recognition for their inflammatory functions, which modulate the immune response during infectious diseases. Platelets contain various immunoreceptors that enable them to act as sentinels to recognize intravascular pathogens. Upon activation, platelets directly limit pathogen growth through the release of AMPs (antimicrobial proteins) and ensure pathogen clearance through activation of immune cells. However, aberrant platelet activation can lead to inflammation and thrombotic events.

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