B Lymphocytes and Adipose Tissue Inflammation | Zendy

Prasad Srikakulapu | Zendy; Coleen A. McNamara | Zendy

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B Lymphocytes and Adipose Tissue Inflammation

Author(s) -

Prasad Srikakulapu,

Coleen A. McNamara

Publication year - 2020

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.119.312467

Subject(s) - adipose tissue , inflammation , immune system , adipose tissue macrophages , dyslipidemia , insulin resistance , biology , medicine , immunology , diabetes mellitus , endocrinology , white adipose tissue

The immune system plays an important role in obesity-induced adipose tissue inflammation and the resultant metabolic dysfunction, which can lead to hypertension, dyslipidemia, and insulin resistance and their downstream sequelae of type 2 diabetes mellitus and cardiovascular disease. While macrophages are the most abundant immune cell type in adipose tissue, other immune cells are also present, such as B cells, which play important roles in regulating adipose tissue inflammation. This brief review will overview B-cell subsets, describe their localization in various adipose depots and summarize our knowledge about the function of these B-cell subsets in regulating adipose tissue inflammation, obesity-induced metabolic dysfunction and atherosclerosis.

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