Open AccessChoosing a Mouse Model of Venous Thrombosis
Author(s) -
José A. Díaz,
Prakash Saha,
Brian C. Cooley,
Olivia R. Palmer,
Steven P. Grover,
Nigel Mackman,
Thomas W. Wakefield,
Peter K. Henke,
Alberto Smith,
Brajesh K. Lal
Publication year - 2019
Publication title -
arteriosclerosis thrombosis and vascular biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.007
H-Index - 270
eISSN - 1524-4636
pISSN - 1079-5642
DOI - 10.1161/atvbaha.118.311818
Subject(s) - venous thrombosis , thrombosis , medicine , deep vein , intensive care medicine , selection (genetic algorithm) , computer science , surgery , machine learning
Murine models are widely used valuable tools to study deep vein thrombosis. Leading experts in venous thrombosis research came together through the American Venous Forum to develop a consensus on maximizing the utility and application of available mouse models of venous thrombosis. In this work, we provide an algorithm for model selection, with discussion of the advantages, disadvantages, and applications of the main mouse models of venous thrombosis. Additionally, we provide a detailed surgical description of the models with guidelines to validate surgical technique.
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