Lymphatic Vasculature Requires Estrogen Receptor-α Signaling to Protect From Lymphedema | Zendy

Florent Morfoisse | Zendy; Florence Tatin | Zendy; B. Chaput | Zendy; Nicole Therville | Zendy; Charlotte Vaysse | Zendy; Raphaël Métivier | Zendy; Julie MalloizelDelaunay | Zendy; Françoise Pujol | Zendy; Anne-Claire Godet | Zendy; Fabienne de Toni | Zendy; Frédéric Boudou | Zendy; Katia Grenier | Zendy; David Dubuc | Zendy; Éric Lacazette | Zendy; AnneCatherine Prats | Zendy; Julie GuillermetGuibert | Zendy; Françoise Lenfant | Zendy; Barbara GarmySusini | Zendy

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Lymphatic Vasculature Requires Estrogen Receptor-α Signaling to Protect From Lymphedema

Author(s) -

Florent Morfoisse,

Florence Tatin,

B. Chaput,

Nicole Therville,

Charlotte Vaysse,

Raphaël Métivier,

Julie MalloizelDelaunay,

Françoise Pujol,

Anne-Claire Godet,

Fabienne de Toni,

Frédéric Boudou,

Katia Grenier,

David Dubuc,

Éric Lacazette,

AnneCatherine Prats,

Julie GuillermetGuibert,

Françoise Lenfant,

Barbara GarmySusini

Publication year - 2018

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.118.310997

Subject(s) - lymphatic system , lymphatic vessel , lymphangiogenesis , estrogen receptor , lymphatic endothelium , tamoxifen , vascular endothelial growth factor c , cancer research , estrogen , endocrinology , medicine , lymphedema , vascular endothelial growth factor , biology , pathology , vascular endothelial growth factor a , cancer , breast cancer , metastasis , vegf receptors

Estrogens exert beneficial effect on the blood vascular system. However, their role on the lymphatic system has been poorly investigated. We studied the protective effect of the 17β estradiol-the most potent endogenous estrogen-in lymphedema-a lymphatic dysfunction, which results in a massive fluid and fat accumulation in the limb.

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