Senescence Alters PPARγ (Peroxisome Proliferator–Activated Receptor Gamma)-Dependent Fatty Acid Handling in Human Adipose Tissue Microvascular Endothelial Cells and Favors Inflammation | Zendy

Anaïs Briot | Zendy; Pauline Decaunes | Zendy; Fanny Volat | Zendy; Chloé Belles | Zendy; Muriel Coupaye | Zendy; Séverine Ledoux | Zendy; Anne Bouloumié | Zendy

Open Access

Senescence Alters PPARγ (Peroxisome Proliferator–Activated Receptor Gamma)-Dependent Fatty Acid Handling in Human Adipose Tissue Microvascular Endothelial Cells and Favors Inflammation

Author(s) -

Anaïs Briot,

Pauline Decaunes,

Fanny Volat,

Chloé Belles,

Muriel Coupaye,

Séverine Ledoux,

Anne Bouloumié

Publication year - 2018

Publication title -

arteriosclerosis thrombosis and vascular biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.007

H-Index - 270

eISSN - 1524-4636

pISSN - 1079-5642

DOI - 10.1161/atvbaha.118.310797

Subject(s) - adipose tissue , inflammation , peroxisome proliferator activated receptor , peroxisome , receptor , microbiology and biotechnology , peroxisome proliferator activated receptor gamma , chemistry , biology , endocrinology , medicine , biochemistry , immunology

Adipose tissue (AT) dysfunction associated with obesity or aging is a major cause for lipid redistribution and the progression of cardiometabolic disorders. Our goal is to decipher the contribution of human AT microvascular endothelial cells (ECs) in the maintenance of fatty acid (FA) fluxes and the impact of senescence on their function.

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